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Article

An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype.

The American journal of pathology - 1 Oct 2009

Posey Karen L, Veerisetty Alka C, Liu Pieman, Wang Huiqiu R, Poindexter Brian J, Bick Roger, Alcorn Joseph L, Hecht Jacqueline T

Abstract excerpt

Cartilage oligomeric matrix protein (COMP) is a pentameric extracellular protein expressed in cartilage and other musculoskeletal tissues. Mutations in the COMP gene cause pseudoachondroplasia (PSACH), a severe dwarfing condition that has a growth plate chondrocyte pathology. PSACH is characterized by intracellular retention of COMP and other extracellular matrix (ECM) proteins, which form an ordered matrix...

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Share to Cartilage Oligomeric Matrix Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19762713
DOI: 10.2353/ajpath.2009.090184
PMCID: PMC2751552

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype.PMID 19762713Read ↗

Pseudoachondroplastic dysplasia: an Iowa review from human to mouse.Semantic proximity Read ↗

Expression of mutant cartilage oligomeric matrix protein in human chondrocytes induces the pseudoachondroplasia phenotype.Semantic proximity Read ↗

A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia.Semantic proximity Read ↗

Retention of cartilage oligomeric matrix protein (COMP) and cell death in redifferentiated pseudoachondroplasia chondrocytes.Semantic proximity Read ↗

Novel therapeutic interventions for pseudoachondroplasia.Semantic proximity Read ↗

Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP.Semantic proximity Read ↗

Chop (Ddit3) Is Essential for D469del-COMP Retention and Cell Death in Chondrocytes in an Inducible Transgenic Mouse Model of PseudoachondroplasiaSemantic proximity Read ↗

Mutant cartilage oligomeric matrix protein (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis.Semantic proximity Read ↗

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COMP mutations, chondrocyte function and cartilage matrix.Semantic proximity Read ↗

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Cartilage oligomeric matrix protein: COMPopathies and beyond.Semantic proximity Read ↗

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