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Article

Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats.

Clinical and experimental immunology - 1 Dec 1998

Carlsén S, Hansson A S, Olsson H, Heinegård D, Holmdahl R

Abstract excerpt

In rheumatoid arthritis peripheral cartilaginous joints are inflamed and eroded. One driving factor may be an immune response towards proteins in the cartilage. Here it is shown that cartilage oligomeric matrix protein (COMP), expressed specifically in cartilage, is arthritogenic in the rat. Both native and denatured rat COMP induced severe arthritis in selected rat strains. The arthritis occurred only in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9844060
DOI: 10.1046/j.1365-2249.1998.00739.x
PMCID: PMC1905143

Genes

COMP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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