Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats.

doi:10.1046/j.1365-2249.1998.00739.x

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Article

Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats.

Clinical and experimental immunology - 1 Dec 1998

Carlsén S, Hansson A S, Olsson H, Heinegård D, Holmdahl R

Abstract excerpt

In rheumatoid arthritis peripheral cartilaginous joints are inflamed and eroded. One driving factor may be an immune response towards proteins in the cartilage. Here it is shown that cartilage oligomeric matrix protein (COMP), expressed specifically in cartilage, is arthritogenic in the rat. Both...

Topics

Animals
Arthritis, Rheumatoid
Cartilage Oligomeric Matrix Protein
Disease Models, Animal
Extracellular Matrix Proteins
Genetic Predisposition to Disease
Glycoproteins
Humans
Matrilin Proteins
Rats

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