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Article

Type 1 Interferons Inhibit Myotube Formation Independently of Upregulation of Interferon-Stimulated Gene 15

4 Jun 2013

Abstract excerpt

INTRODUCTION: Type 1 interferon (IFN)-inducible genes and their inducible products are upregulated in dermatomyositis muscle. Of these, IFN-stimulated gene 15 (ISG15) is one of the most upregulated, suggesting its possible involvement in the pathogenesis of this disease. To test this postulate, we developed a model of type 1 IFN mediated myotube toxicity and assessed whether or not downregulation of ISG15...

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Share to Inflammatory Myopathies and Dermatomyositis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23750257
DOI: 10.1371/journal.pone.0065362

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