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Article

A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.

The Journal of biological chemistry - 26 Jul 2013

Gadd Morgan S, Jacques David A, Nisevic Ivan, Craig Vanessa J, Kwan Ann H, Guss J Mitchell, Matthews Jacqueline M

Abstract excerpt

Islet 1 (Isl1) is a transcription factor of the LIM-homeodomain (LIM-HD) protein family and is essential for many developmental processes. LIM-HD proteins all contain two protein-interacting LIM domains, a DNA-binding homeodomain (HD), and a C-terminal region. In Isl1, the C-terminal region also contains the LIM homeobox 3 (Lhx3)-binding domain (LBD), which interacts with the LIM domains of Lhx3. The LIM domains...

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Identifiers

PMID: 23750000
DOI: 10.1074/jbc.M113.478586
PMCID: PMC3724647

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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