Article
Solution structure and interaction with copper in vitro and in living cells of the first BIR domain of XIAP.
Scientific reports - 30 Nov 2017
Hou Meng-Meng, Polykretis Panagis, Luchinat Enrico, Wang Xiao, Chen Shen-Na, Zuo Hui-Hui, Yang Yin, Chen Jia-Liang, Ye Yansheng, Li Conggang, Banci Lucia, Su Xun-Cheng
Abstract excerpt
The X-chromosome linked inhibitor of apoptosis (XIAP) is a multidomain metalloprotein involved in caspase inhibition and in copper homeostasis. It contains three zinc-binding baculoviral IAP repeats (BIR) domains, which are responsible for caspase interaction. Recently, it has been suggested that the BIR domains can bind copper, however high resolution data on such interaction is missing. Here we characterize by...
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