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Article

Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase.

Structure (London, England : 1993) - 1 Nov 2005

Li Shiqing, Depetris Rafael S, Barford David, Chernoff Jonathan, Hubbard Stevan R

Abstract excerpt

Protein tyrosine phosphatase 1B (PTP1B) is a highly specific negative regulator of insulin receptor signaling in vivo. The determinants of PTP1B specificity for the insulin receptor versus other receptor tyrosine kinases are largely unknown. Here, we report a crystal structure at 2.3 A resolution of the catalytic domain of PTP1B (trapping mutant) in complex with the phosphorylated tyrosine kinase domain of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 1

Source

Identifiers

PMID: 16271887
DOI: 10.1016/j.str.2005.07.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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