Article
Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain.
Nature - 26 Apr 1990
Karlsson O, Thor S, Norberg T, Ohlsson H, Edlund T
Abstract excerpt
The activity of the rat insulin I gene enhancer is mainly dependent on two cis-acting protein-binding domains. Here we report the isolation of a complementary DNA encoding a protein, Isl-1, that binds to one of these domains. Isl-1 contains a homeodomain with greatest similarity to those of the C...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis
- Cloning, Molecular
- Cysteine
- DNA
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Escherichia coli
- Genes, Homeobox
- Histidine
- Homeodomain Proteins
- Insulin
- LIM-Homeodomain Proteins
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins