Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Uridylation prevents 3' trimming of oligoadenylated mRNAs.

Nucleic acids research - 1 Aug 2013

Sement François Michaël, Ferrier Emilie, Zuber Hélène, Merret Rémy, Alioua Malek, Deragon Jean-Marc, Bousquet-Antonelli Cécile, Lange Heike, Gagliardi Dominique

Abstract excerpt

Degradation of mRNAs is usually initiated by deadenylation, the shortening of long poly(A) tails to oligo(A) tails of 12-15 As. Deadenylation leads to decapping and to subsequent 5' to 3' degradation by XRN proteins, or alternatively 3' to 5' degradation by the exosome. Decapping can also be induced by uridylation as shown for the non-polyadenylated histone mRNAs in humans and for several mRNAs in...

Topics

Join the communities discussing this publication.

Adenine Nucleotides
Arabidopsis Proteins
Oligoribonucleotides
Polyribosomes
RNA Nucleotidyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Uridine Monophosphate

Source

Open in PubMed Open full text

Identifiers

PMID: 23748567
DOI: 10.1093/nar/gkt465
PMCID: PMC3737552

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Uridylation prevents 3' trimming of oligoadenylated mRNAs.PMID 23748567Read ↗

AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets.Semantic proximity Read ↗

mRNA 3' tagging is induced by nonsense-mediated decay and promotes ribosome dissociation.Semantic proximity Read ↗

Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation.Semantic proximity Read ↗

To polyadenylate or to deadenylateSemantic proximity Read ↗

Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure.Semantic proximity Read ↗

The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation.Semantic proximity Read ↗

Loss of Arabidopsis 5'-3' Exoribonuclease AtXRN4 Function Enhances Heat Stress Tolerance of Plants Subjected to Severe Heat Stress.Semantic proximity Read ↗

Nonsense-Mediated RNA Decay Factor UPF1 Is Critical for Posttranscriptional and Translational Gene Regulation in Arabidopsis.Semantic proximity Read ↗

Molecular Insights into mRNA Polyadenylation and DeadenylationSemantic proximity Read ↗

The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses.Semantic proximity Read ↗

In plants, decapping prevents RDR6-dependent production of small interfering RNAs from endogenous mRNAs.Semantic proximity Read ↗

The EDC4-XRN1 axis controls P-body dynamics to link mRNA decapping with decaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.