Article
The Arabidopsis homologs of CCR4-associated factor 1 show mRNA deadenylation activity and play a role in plant defence responses.
Cell research - 1 Mar 2009
Liang Wenxing, Li Changbao, Liu Fang, Jiang Hongling, Li Shuyu, Sun Jiaqiang, Wu Xiaoyan, Li Chuanyou
Abstract excerpt
Messenger RNA (mRNA) turnover in eukaryotic cells begins with shortening of the poly (A) tail at the 3' end, a process called deadenylation. In yeast, the deadenylation reaction is predominantly mediated by CCR4 and CCR4-associated factor 1 (CAF1), two components of the well-characterised protein complex named CCR4-NOT. We report here that AtCAF1a and AtCAF1b, putative Arabidopsis homologs of the yeast CAF1 gene,...
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