Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular dissection of human Argonaute proteins by DNA shuffling.

Nature structural & molecular biology - 1 Jul 2013

Schürmann Nina, Trabuco Leonardo G, Bender Christian, Russell Robert B, Grimm Dirk

Abstract excerpt

A paramount task in RNA interference research is to decipher the complex biology of cellular effectors, exemplified in humans by four pleiotropic Argonaute proteins (Ago1-Ago4). Here, we exploited DNA family shuffling, a molecular evolution technology, to generate chimeric Ago protein libraries f...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Argonaute Proteins
Share to Consensus Sequence
Share to Directed Molecular Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Recombinant

Share to DNA Shuffling

Share to Eukaryotic Initiation Factors

Share to Gene Library

Share to RNA Processing, Post-Transcriptional

Source

Identifiers

PMID: 23748378
DOI: 10.1038/nsmb.2607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23748378-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular dissection of human Argonaute proteins by DNA shuffling.PMID 23748378Read ↗

Structural and evolutionary determinants of Argonaute functionSemantic proximity Read ↗

Lessons on RNA silencing mechanisms in plants from eukaryotic argonaute structures.Semantic proximity Read ↗

The Crystal Structure of Human Argonaute2Semantic proximity Read ↗

Programmed Manipulation of RNA Targets By Human Argonaute 2Semantic proximity Read ↗

RNA-guided RNA silencing by an Asgard archaeal ArgonauteSemantic proximity Read ↗

Directed evolution of proteins by exon shufflingSemantic proximity Read ↗

Structural basis for differential targeting properties of small RNAs in plants and animalsSemantic proximity Read ↗

Structural basis for gene silencing by siRNAs in humansSemantic proximity Read ↗

EXTENDED TUDOR-DOMAINS of the piRNA BIOGENESIS PATHWAY HAVE RNA-SPECIFIC NUCLEASE ACTIVITYSemantic proximity Read ↗

Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.Semantic proximity Read ↗

Creative destruction: New protein folds from old.Semantic proximity Read ↗

AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.