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Article

Modulation of the endogenous antioxidants paraoxonase-1 and urate by pesticide exposure and genetic variants of xenobiotic-metabolizing enzymes.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association - 1 Nov 2013

Hernández Antonio F, Gil Fernando, Lacasaña Marina, Rodríguez-Barranco Miguel, Gómez-Martin Antonio, Lozano David, Pla Antonio

Abstract excerpt

This study evaluated the association between pesticide exposure in farmworkers and plasma levels of the endogenous antioxidants urate and paraoxonase-1 (PON1) enzyme activities (paraoxonase, arylesterase and diazoxonase, three substrate-specific assays for measuring PON1 function) by using generalized estimating equations (GEEs). Decreases in plasma and erythrocyte cholinesterases (BChE and AChE, respectively)...

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Source

Identifiers

PMID: 23747713
DOI: 10.1016/j.fct.2013.05.039

Genes

PON1
BCHE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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