Article
The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel.
Nature communications - 15 Jul 2023
Irie Katsumasa, Oda Yoshinori, Sumikama Takashi, Oshima Atsunori, Fujiyoshi Yoshinori
Abstract excerpt
Divalent cation block is observed in various tetrameric ion channels. For blocking, a divalent cation is thought to bind in the ion pathway of the channel, but such block has not yet been directly observed. So, the behaviour of these blocking divalent cations remains still uncertain. Here, we elucidated the mechanism of the divalent cation block by reproducing the blocking effect into NavAb, a well-studied...
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