Bromodeoxyuridine (BrdU) template and thymidine pool effects on high frequencies of sister-chromatid exchange (SCE) in Bloom syndrome cells and a mutant cell line (AsHa) originated from ataxia telangiectasia.

Abstract excerpt

The effect of bromodeoxyuridine (BrdU)-substituted DNA template and thymidine (dT) pool on excess sister-chromatid exchanges (SCEs) was studied in Bloom syndrome (BS) cells and an ataxia telangiectasia (AT)-derived mutant cell line (AsHa). When BS endomitotic cells were labeled with low and high (or high and low) BrdU concentrations during S1 and S2, only the BrdU concentration during S1 phase affected the...

Topics

• Ataxia Telangiectasia
• Bloom Syndrome
• Bromodeoxyuridine
• Cell Fusion
• Cell Line
• Diploidy
• Dose-Response Relationship, Drug
• Humans
• Mitosis
• Mutation
• Sister Chromatid Exchange