Article
Functional analysis of the EspR binding sites upstream of espR in Mycobacterium tuberculosis.
Current microbiology - 1 Nov 2013
Cao Guangxiang, Howard Susan T, Zhang Peipei, Hou Guihua, Pang Xiuhua
Abstract excerpt
The ESX-1 secretion system exports substrate proteins into host cells and is crucial for the pathogenesis of Mycobacterium tuberculosis. EspR is one of the characterized transcriptional regulators that modulates the ESX-1 system by binding the conserved EspR binding sites in the promoter of espA, the encoding gene of EspA, which is also a substrate protein of the ESX-1 system and is required for the ESX-1...
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