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Article

MprAB regulates the espA operon in Mycobacterium tuberculosis and modulates ESX-1 function and host cytokine response.

Journal of bacteriology - 1 Jan 2013

Pang Xiuhua, Samten Buka, Cao Guangxiang, Wang Xisheng, Tvinnereim Amy R, Chen Xiu-Lan, Howard Susan T

Abstract excerpt

The ESX-1 secretion system exports the immunomodulatory protein ESAT-6 and other proteins important in the pathogenesis of Mycobacterium tuberculosis. Components and substrates of ESX-1 are encoded at several loci, but the regulation of the encoding genes is only partially understood. In this study, we investigated the role of the MprAB two-component system in the regulation of ESX-1 activity. We determined that...

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Identifiers

PMID: 23104803
DOI: 10.1128/JB.01067-12
PMCID: PMC3536182

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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