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Article

Novel MprA binding motifs in the phoP regulatory region in Mycobacterium tuberculosis.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2018

Zhang Peipei, Fu Jiafang, Zong Gongli, Liu Meng, Pang Xiuhua, Cao Guangxiang

Abstract excerpt

MprAB and PhoPR are important two-component systems (TCSs) in Mycobacterium tuberculosis, and both regulate EspR, a key regulator of the ESX-1 secretion system. Although previous studies suggest that the response regulator PhoP does not directly regulate mprA, the interplay between MprAB and PhoPR remains unclear. In this study, we found that the response regulator MprA can bind to the phoP promoter. Four repeat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30205970
DOI: 10.1016/j.tube.2018.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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