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A novel Amh -Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads

12 Sept 2014

Abstract excerpt

Cell ablation technology is useful for studying specific cell lineages in a developing organ in vivo. Herein, we established a novel anti-Müllerian hormone (AMH)-toxin receptor-mediated cell knockout (Treck) mouse line, in which the diphtheria toxin (DT) receptor was specifically activated in Sertoli and granulosa cells in postnatal testes and ovaries respectively. In the postnatal testes of Amh-Treck transgenic...

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PMID: 25212783
DOI: 10.1530/rep-14-0171

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