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Article

Conditionally-live attenuated SIV upregulates global T effector memory cell frequency under replication permissive conditions.

Retrovirology - 5 Jun 2013

Manoussaka Maria S, Berry Neil, Ferguson Deborah, Stebbings Richard, Robinson Mark, Ham Claire, Page Mark, Li Bo, Das Atze T, Berkhout Ben, Almond Neil, Cranage Martin P

Abstract excerpt

BACKGROUND: Live attenuated SIV induces potent protection against superinfection with virulent virus; however the mechanism of this vaccine effect is poorly understood. Such knowledge is important for the development of clinically acceptable vaccine modalities against HIV. RESULTS: Using a novel, doxycycline dependent, replication-competent live-attenuated SIVmac239Δnef (SIV-rtTAΔnef), we show that under...

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Source

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Identifiers

PMID: 23738926
DOI: 10.1186/1742-4690-10-59
PMCID: PMC3706341

Genes

CCR7
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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