Article
Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques.
Virology - 10 Nov 2008
Mason Rosemarie D, Rose Robert De, Seddiki Nabila, Kelleher Anthony D, Kent Stephen J
Abstract excerpt
CD4+ T lymphocyte subsets are targeted to different degrees by SIV infection. We studied central memory, effector memory, naïve, and regulatory T cell levels longitudinally in 11 SIV(mac251)-infected pigtail macaques. Depletion of CD28+CD95+ central memory CD4+ T cells, but not other populations, correlated with both SIV viral load and disease progression. A low pre-infection level of central memory CD4+ T cells...
Topics
- Animals
- CD4 Antigens
- CD4 Lymphocyte Count
- CD4-Positive T-Lymphocytes
- Disease Progression
- Immunologic Memory
- Macaca nemestrina
- Phenotype
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus
- T-Lymphocytes, Regulatory
- Viremia