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Article

DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway.

PloS one - 1 Jan 2013

Chen Yin-Ju, Lee Li-Yu, Chao Yin-Ka, Chang Joseph T, Lu Ya-Ching, Li Hsiao-Fang, Chiu Ching-Chi, Li Yi-Chen, Li Yan-Liang, Chiou Jeng-Fong, Cheng Ann-Joy

Abstract excerpt

Desmoglein 3 (DSG3) is a component of the desmosome, which confers strong cell-cell adhesion. Previously, an oncogenic function of DSG3 has been found in head neck cancer (HNC). Here, we investigated how this molecule contributes to the malignant phenotype. Because DSG3 is associated with plakoglobin, we examined whether these phenotypic alterations were mediated through the plakoglobin molecule....

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Source

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Identifiers

PMID: 23737966
DOI: 10.1371/journal.pone.0064088
PMCID: PMC3667790

Genes

DSG3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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