Article
Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Aug 2016
Sumida Tomoki, Ishikawa Akiko, Nakano Hiroyuki, Yamada Tomohiro, Mori Yoshihide, Desprez Pierre-Yves
Abstract excerpt
Inhibitors of DNA-binding (ID) proteins are negative regulators of basic helix-loop-helix transcription factors and generally stimulate cell proliferation and inhibit differentiation. We previously determined that ID1 was highly expressed in aggressive salivary gland cancer (SGC) cells in culture. Here, we show that ID2 is also expressed in aggressive SGC cells. ID2 knockdown triggers important changes in cell...
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