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Article

Inferring haplotype/disease association by joint use of case-parents trios and case-parent pairs.

Annals of human genetics - 1 May 2010

Hu Yue-Qing, Zhou Ji-Yuan

Abstract excerpt

Recently interest has been increasing in genetic association studies using several closely linked loci. The HAP-TDT method, which uses case-parents trios is powerful for such a task. However, it is not uncommon in practice that one parent is missing for some reason, such as late onset. The case-parents trios are thus reduced to case-parent pairs. Discarding such data could lead to a severe loss of power. In this...

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PMID: 20529016
DOI: 10.1111/j.1469-1809.2010.00563.x

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