Article
Discovering motifs that induce sequencing errors.
BMC bioinformatics - 1 Jan 2013
Allhoff Manuel, Schönhuth Alexander, Martin Marcel, Costa Ivan G, Rahmann Sven, Marschall Tobias
Abstract excerpt
BACKGROUND: Elevated sequencing error rates are the most predominant obstacle in single-nucleotide polymorphism (SNP) detection, which is a major goal in the bulk of current studies using next-generation sequencing (NGS). Beyond routinely handled generic sources of errors, certain base calling errors relate to specific sequence patterns. Statistically principled ways to associate sequence patterns with base...
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