Article
Single nucleotide polymorphisms in the matrix metalloproteinase gene family and the frequency and duration of gastroesophageal reflux disease influence the risk of esophageal adenocarcinoma.
International journal of cancer - 1 Dec 2012
Cheung Winson Y, Zhai Rihong, Bradbury Penny, Hopkins Jessica, Kulke Matthew H, Heist Rebecca S, Asomaning Kofi, Ma Clement, Xu Wei, Wang Zhaoxi, Hooshmand Suzanne, Su Li, Christiani David C, Liu Geoffrey
Abstract excerpt
The matrix metalloproteinase (MMP) family of proteins mediates various cellular pathways, including apoptosis and angiogenesis. Polymorphisms of MMP genes are associated with increased esophageal adenocarcinoma (EAC) risk. Gastroesophageal reflux disease (GERD) is an established EAC risk factor. We examined whether MMP polymorphism-EAC risk is modified by GERD. In total, 309 EAC patients and 279 frequency-matched...
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