Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma.

International journal of cancer - 1 Jul 2008

Doecke James, Zhao Zhen Zhen, Pandeya Nirmala, Sadeghi Shahram, Stark Mitchell, Green Adèle C, Hayward Nicholas K, Webb Penelope M, Whiteman David C

Abstract excerpt

Rates of adenocarcinoma of the esophagus (EAC) and esophago-gastric junction (EGJAC) have increased rapidly in recent decades. The primary risk factors, gastro-esophageal acid reflux and smoking, are potentially genotoxic through the generation of N-nitroso compounds. The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is the major cellular defense against alkylating DNA damage. We compared...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Australia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Mass Index

Share to DNA Modification Methylases

Share to DNA Repair Enzymes

Share to Esophageal Neoplasms

Share to Multivariate Analysis

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 18386788
DOI: 10.1002/ijc.23410

Genes

MGMT
ERCC1
XRCC1

Variants

rs12269324
rs12269324
rs12269324
rs12269324
rs12269324
rs12269324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in MGMT and DNA repair genes and the risk of esophageal adenocarcinoma.PMID 18386788Read ↗

Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinomaSemantic proximity Read ↗

XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk.Semantic proximity Read ↗

Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk.Semantic proximity Read ↗

DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.Semantic proximity Read ↗

Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma.Semantic proximity Read ↗

Selected polymorphisms of DNA repair genes and risk of pancreatic cancer.Semantic proximity Read ↗

The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden.Semantic proximity Read ↗

The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract.Semantic proximity Read ↗

DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study.Semantic proximity Read ↗

Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway.Semantic proximity Read ↗

Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus.Semantic proximity Read ↗

A pooled analysis of the ERCC2 Asp312Asn polymorphism and esophageal cancer susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.