Article
Insights into the mechanism by which interferon-γ basic amino acid clusters mediate protein binding to heparan sulfate.
Journal of the American Chemical Society - 26 Jun 2013
Saesen Els, Sarrazin Stéphane, Laguri Cédric, Sadir Rabia, Maurin Damien, Thomas Aline, Imberty Anne, Lortat-Jacob Hugues
Abstract excerpt
The extensive functional repertoire of heparin and heparan sulfate, which relies on their ability to interact with a large number of proteins, has recently emerged. To understand the forces that drive such interactions the binding of heparin to interferon-γ (IFNγ), used as a model system, was inv...
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