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Article

Mutation in the CX3C Motif of G Protein Disrupts Its Interaction with Heparan Sulfate: A Calorimetric, Spectroscopic, and Molecular Docking Study.

International journal of molecular sciences - 9 Feb 2022

Hamza Abu, Samad Abdus, Parray Zahoor Ahmad, Ara Sajda, Ahmed Anwar, Almajhdi Fahad N, Hussain Tajamul, Islam Asimul, Parveen Shama

Abstract excerpt

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in children and infants. To date, there is no effective vaccine available against RSV. Heparan sulfate is a type of glycosaminoglycan that aids in the attachment of the RSV to the host cell membrane via the G protein. In the present study, the effect of amino acid substitution on the structure and stability of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35216066
DOI: 10.3390/ijms23041950
PMCID: PMC8880246

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