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Article

NFAT5 binds to the TNF promoter distinctly from NFATp, c, 3 and 4, and activates TNF transcription during hypertonic stress alone.

Nucleic acids research - 1 Jan 2005

Esensten Jonathan H, Tsytsykova Alla V, Lopez-Rodriguez Cristina, Ligeiro Filipa A, Rao Anjana, Goldfeld Anne E

Abstract excerpt

Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays an important role in a variety of infectious and autoimmune disorders. Its transcription is regulated in a stimulus- and cell-type-specific manner via the recruitment of distinct DNA/activator complexes forming secondary structures or enhanceosomes. NFATp, a member of the nuclear factor of activated T cells (NFAT) family of transcription...

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Source

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Identifiers

PMID: 16027109
DOI: 10.1093/nar/gki701
PMCID: PMC1175021

Genes

TNF
NFAT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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