Article
Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death.
Circulation research - 12 May 2006
Terentyev Dmitry, Nori Alessandra, Santoro Massimo, Viatchenko-Karpinski Serge, Kubalova Zuzana, Gyorke Inna, Terentyeva Radmila, Vedamoorthyrao Srikanth, Blom Nico A, Valle Giorgia, Napolitano Carlo, Williams Simon C, Volpe Pompeo, Priori Silvia G, Gyorke Sandor
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic disorder associated with mutations in the cardiac ryanodine receptor (RyR2) and cardiac calsequestrin (CASQ2) genes. Previous in vitro studies suggested that RyR2 and CASQ2 interact as parts of a multimolecular Ca(2+)-signaling complex; however, direct evidence for such interactions and their potential significance to...
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