Article
Unraveling the mechanisms of catecholaminergic polymorphic ventricular tachycardia.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference - 1 Jan 2006
Iyer Vivek, Armoundas Antonis A
Abstract excerpt
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a heritable arrhythmia unmasked by exertion or stress, characterized by triggered activity and sudden cardiac death in affected patients. In this study we used a mathematical model to simulate two mutations linked toCPVT, in cardiac calsequestrin (CSQN2) and the ryanodine receptor (RyR2). The aim of the present study is to characterize the mutations...
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