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Article

MICA, a gene contributing strong susceptibility to ankylosing spondylitis.

Annals of the rheumatic diseases - 1 Aug 2014

Zhou Xiaodong, Wang Jiucun, Zou Hejian, Ward Michael M, Weisman Michael H, Espitia Maribel G, Xiao Xiangjun, Petersdorf Effie, Mignot Emmanuel, Martin Javier, Gensler Lianne S, Scheet Paul, Reveille John D

Abstract excerpt

OBJECTIVE: The human major histocompatibility complex class I chain-related gene A (MICA) controls the immune process by balancing activities of natural killer cells, γδ T cells and αβ CD8 T cells, and immunosuppressive CD4 T cells. MICA is located near HLA-B on chromosome 6. Recent genomewide association studies indicate that genes most strongly linked to ankylosing spondylitis (AS) susceptibility come from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23727634
DOI: 10.1136/annrheumdis-2013-203352
PMCID: PMC3874076

Genes

MICA

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Related research

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MICA, a gene contributing strong susceptibility to ankylosing spondylitis.PMID 23727634Read ↗

[Disequilibrium linkage between the polymorphism in exons 2, 3 and 4 of the MICA gene and HLA-B antigen of patient with ankylosing spondylitis].Semantic proximity Read ↗

MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis.Semantic proximity Read ↗

Association of HLA genes with ankylosing spondylitis in Han population of eastern China.Semantic proximity Read ↗

MICA allele typing of HLA-B27 positive Japanese patients with seronegative spondylarthropathies and healthy individuals: differential linkage disequilibrium with HLA-B27 subtypes.Semantic proximity Read ↗

Meta-analysis of the association between functional MICA-TM polymorphisms and systemic lupus erythematosus, rheumatoid arthritis and ankylosing spondylitis.Semantic proximity Read ↗

Joint study of the associations of HLA-B and the transmembrane short tandem repeat polymorphism of MICA protein with alopecia areata shows independent associations of both with the disease.Semantic proximity Read ↗

Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.Semantic proximity Read ↗

MICA polymorphism: biology and importance in immunity and disease.Semantic proximity Read ↗

Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitisSemantic proximity Read ↗

An update on the contribution of the MHC to AS susceptibility.Semantic proximity Read ↗

Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitisSemantic proximity Read ↗

Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study.Semantic proximity Read ↗

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