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Article

Targeting the MICA-mediated oxidative stress-immune axis: a novel therapeutic strategy for ankylosing spondylitis.

Clinical and experimental rheumatology - 1 Sept 2026

He Rongqing, Huang Zuyuan, Qin Xiaopeng, Xue Jiang, Chen Jiarui, Qin Boli, Liu Dequan, Wu Songze, Kang Tao, Zhan Xinli, Liu Chong

Abstract excerpt

OBJECTIVES: Ankylosing spondylitis (AS) involves a complex interplay between oxidative stress (OS) and immune dysregulation, yet the precise molecular links involved remain unclear. METHODS: OS-related genes were obtained from the GeneCards database. Differential expression analysis was performed on mRNA microarray (MA) data to identify OS-associated differentially expressed genes (DEGs). A two-sample Mendelian...

Read the complete abstract on PubMed

Topics

Humans
Spondylitis, Ankylosing
Oxidative Stress
Histocompatibility Antigens Class I
T-Lymphocytes, Regulatory

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Phenotype

Gene Expression Profiling

Databases, Genetic

Source

Identifiers

PMID: 41930655
DOI: 10.55563/clinexprheumatol/ngvjin

Genes

MICA
CD28

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

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