Article
[Disequilibrium linkage between the polymorphism in exons 2, 3 and 4 of the MICA gene and HLA-B antigen of patient with ankylosing spondylitis].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Aug 2006
Su Hong, Wang Bao-long, Zhang Xiu-jun, Hao Jia-hu, Xiao Qin, Ye Dong-qing
Abstract excerpt
OBJECTIVE: To investigate the association between the exons 2 to 4 of the MICA gene and ankylosing spondylitis (AS). METHODS: By PCR-SSOP, DNA samples from 56 AS patients and 112 random healthy individuals, as normal control were genotyped to analyse the polymorphism in exons 2, 3, 4 of the MICA alleles. RESULTS: MICA*008 was dominant in MICA allele,accounted for 32.14% and 30.36% in AS patients and normal...
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