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Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

25 Jul 2017

Abstract excerpt

Abstract Background Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease. Little is known about the potential role of DNA methylation in the pathogenesis of AS. This study was undertaken to explore the potential role of DNA methylation in the genetic mechanism of AS. Methods In this study, we compared the genome-wide DNA methylation profiles of peripheral blood mononuclear cells (PBMCs)...

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PMID: 28743287
DOI: 10.1186/s13075-017-1382-1

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