Article
The parallel reaction monitoring method contributes to a highly sensitive polyubiquitin chain quantification.
Biochemical and biophysical research communications - 28 Jun 2013
Tsuchiya Hikaru, Tanaka Keiji, Saeki Yasushi
Abstract excerpt
Ubiquitylation is an essential posttranslational protein modification that is implicated in a diverse array of cellular functions. Although cells contain eight structurally distinct types of polyubiquitin chains, detailed function of several chain types including K29-linked chains has remained largely unclear. Current mass spectrometry (MS)-based quantification methods are highly inefficient for low abundant...
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