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Article

Engineering the orthogonal ubiquitin E1-E2 pairs for identification of K27 chain linkage substrates.

International journal of biological macromolecules - 1 Dec 2024

Wang Yanan, Lee Priscilla Ann Hweek, Sun Yiheng, Cai Kang, Jin Bo, Xie Qiuling, Xu Shanshan, Jiao Xianting, Zhao Bo

Abstract excerpt

Ubiquitination is one kind of crucial protein post-translational modification (PTM) in eukaryotic cells, forming sorts of types of polyubiquitin chain linkages on the substrates. Ubiquitin conjugating enzymes (E2s) play an essential role in the formation of ubiquitin chains. However, the mechanism of the formation of atypical chain (such as K27) and the identification of the related substrates are not well...

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PMID: 39566774
DOI: 10.1016/j.ijbiomac.2024.137837

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