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Article

Coupling between trans/cis proline isomerization and protein stability in staphylococcal nuclease.

Protein science : a publication of the Protein Society - 1 Sept 1996

Truckses D M, Somoza J R, Prehoda K E, Miller S C, Markley J L

Abstract excerpt

The nucleases A produced by two strains of Staphylococcus aureus, which have different stabilities, differ only in the identity of the single amino acid at residue 124. The nuclease from the Foggi strain of S. aureus (by convention nuclease WT), which contains His124, is 1.9 kcal.mol-1 less stable (at pH 5.5 and 20 degrees C) than the nuclease from the V8 strain (by convention nuclease H124L), which contains...

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Identifiers

PMID: 8880915
DOI: 10.1002/pro.5560050917
PMCID: PMC2143535

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