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Article

ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.

Cell - 14 Jan 2005

Xu Xiangdong, Yang Dongmei, Ding Jian-Hua, Wang Wang, Chu Pao-Hsien, Dalton Nancy D, Wang Huan-You, Bermingham John R, Ye Zhen, Liu Forrest, Rosenfeld Michael G, Manley James L, Ross John, Chen Ju, Xiao Rui-Ping, Cheng Heping, Fu Xiang-Dong

Abstract excerpt

The transition from juvenile to adult life is accompanied by programmed remodeling in many tissues and organs, which is key for organisms to adapt to the demand of the environment. Here we report a novel regulated alternative splicing program that is crucial for postnatnal heart remodeling in the mouse. We identify the essential splicing factor ASF/SF2 as a key component of the program, regulating a restricted...

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Identifiers

PMID: 15652482
DOI: 10.1016/j.cell.2004.11.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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