Article
Genotype and tumor locus determine expression profile of pseudohypoxic pheochromocytomas and paragangliomas.
Neoplasia (New York, N.Y.) - 1 Apr 2013
Shankavaram Uma, Fliedner Stephanie M J, Elkahloun Abdel G, Barb Jenifer J, Munson Peter J, Huynh Thanh T, Matro Joey C, Turkova Hana, Linehan W Marston, Timmers Henri J, Tischler Arthur S, Powers James F, de Krijger Ronald, Baysal Bora E, Takacova Martina, Pastorekova Silvia, Gius David, Lehnert Hendrik, Camphausen Kevin, Pacak Karel
Abstract excerpt
Pheochromocytomas (PHEOs) and paragangliomas (PGLs) related to mutations in the mitochondrial succinate dehydrogenase (SDH) subunits A, B, C, and D, SDH complex assembly factor 2, and the von Hippel-Lindau (VHL) genes share a pseudohypoxic expression profile. However, genotype-specific differences in expression have been emerging. Development of effective new therapies for distinctive manifestations, e.g., a high...
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