Article
Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro.
Lipids in health and disease - 30 May 2013
Solakivi Tiina, Kunnas Tarja, Jaakkola Olli, Renko Jaana, Lehtimäki Terho, Nikkari Seppo T
Abstract excerpt
BACKGROUND: Oxidative modification of low-density lipoprotein (LDL) is a key event in the oxidation hypothesis of atherogenesis. We have previously shown that HDL does not protect LDL from oxidation in vitro, but is in fact oxidized fastest of all lipoproteins due to its rich polyunsaturated fatty acid (PUFA) composition, which is oxidation promoting. Evidence has accumulated to show that in addition to diet,...
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