Article
Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2016
Sundaresan Tilak K, Sequist Lecia V, Heymach John V, Riely Gregory J, Jänne Pasi A, Koch Walter H, Sullivan James P, Fox Douglas B, Maher Robert, Muzikansky Alona, Webb Andrew, Tran Hai T, Giri Uma, Fleisher Martin, Yu Helena A, Wei Wen, Johnson Bruce E, Barber Thomas A, Walsh John R, Engelman Jeffrey A, Stott Shannon L, Kapur Ravi, Maheswaran Shyamala, Toner Mehmet, Haber Daniel A
Abstract excerpt
PURPOSE: The T790M gatekeeper mutation in the EGFR is acquired by some EGFR-mutant non-small cell lung cancers (NSCLC) as they become resistant to selective tyrosine kinase inhibitors (TKI). As third-generation EGFR TKIs that overcome T790M-associated resistance become available, noninvasive approaches to T790M detection will become critical to guide management. EXPERIMENTAL DESIGN: As part of a...
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