Imputation-based meta-analysis of severe malaria in three African populations.

doi:10.1371/journal.pgen.1003509

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Article

Imputation-based meta-analysis of severe malaria in three African populations.

PLoS genetics - 1 May 2013

Band Gavin, Le Quang Si, Jostins Luke, Pirinen Matti, Kivinen Katja, Jallow Muminatou, Sisay-Joof Fatoumatta, Bojang Kalifa, Pinder Margaret, Sirugo Giorgio, Conway David J, Nyirongo Vysaul, Kachala David, Molyneux Malcolm, Taylor Terrie, Ndila Carolyne, Peshu Norbert, Marsh Kevin, Williams Thomas N, Alcock Daniel, Andrews Robert, Edkins Sarah, Gray Emma, Hubbart Christina, Jeffreys Anna, Rowlands Kate, Schuldt Kathrin, Clark Taane G, Small Kerrin S, Teo Yik Ying, Kwiatkowski Dominic P, Rockett Kirk A, Barrett Jeffrey C, Spencer Chris C A

Abstract excerpt

Combining data from genome-wide association studies (GWAS) conducted at different locations, using genotype imputation and fixed-effects meta-analysis, has been a powerful approach for dissecting complex disease genetics in populations of European ancestry. Here we investigate the feasibility of applying the same approach in Africa, where genetic diversity, both within and between populations, is far more...

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PMID: 23717212
DOI: 10.1371/journal.pgen.1003509
PMCID: PMC3662650

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