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Article

RNA-mediated epigenetic heredity requires the cytosine methyltransferase Dnmt2.

PLoS genetics - 1 May 2013

Kiani Jafar, Grandjean Valérie, Liebers Reinhard, Tuorto Francesca, Ghanbarian Hossein, Lyko Frank, Cuzin François, Rassoulzadegan Minoo

Abstract excerpt

RNA-mediated transmission of phenotypes is an important way to explain non-Mendelian heredity. We have previously shown that small non-coding RNAs can induce hereditary epigenetic variations in mice and act as the transgenerational signalling molecules. Two prominent examples for these paramutations include the epigenetic modulation of the Kit gene, resulting in altered fur coloration, and the modulation of the...

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PMID: 23717211
DOI: 10.1371/journal.pgen.1003498
PMCID: PMC3662642

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