Article
RNA induction and inheritance of epigenetic cardiac hypertrophy in the mouse.
Developmental cell - 1 Jun 2008
Wagner Kay D, Wagner Nicole, Ghanbarian Hossein, Grandjean Valérie, Gounon Pierre, Cuzin François, Rassoulzadegan Minoo
Abstract excerpt
Epigenetic regulation shapes normal and pathological mammalian development and physiology. Our previous work showed that Kit RNAs injected into fertilized mouse eggs can produce heritable epigenetic defects, or paramutations, with relevant loss-of-function pigmentation phenotypes, which affect adult phenotypes in multiple succeeding generations of mice. Here, we illustrate the relevance of paramutation to...
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