Article
No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2013
Youngson Neil A, Epp Trevor, Roberts Amity R, Daxinger Lucia, Ashe Alyson, Huang Edward, Lester Krystal L, Harten Sarah K, Kay Graham F, Cox Timothy, Matthews Jacqueline M, Chong Suyinn, Whitelaw Emma
Abstract excerpt
Observations of inherited phenotypes that cannot be explained solely through genetic inheritance are increasing. Evidence points to transmission of non-DNA molecules in the gamete as mediators of the phenotypes. However, in most cases it is unclear what the molecules are, with DNA methylation, chromatin proteins, and small RNAs being the most prominent candidates. From a screen to generate novel mouse mutants of...
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