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Article

RNA-mediated non-mendelian inheritance of an epigenetic change in the mouse.

Nature - 25 May 2006

Rassoulzadegan Minoo, Grandjean Valérie, Gounon Pierre, Vincent Stéphane, Gillot Isabelle, Cuzin François

Abstract excerpt

Paramutation is a heritable epigenetic modification induced in plants by cross-talk between allelic loci. Here we report a similar modification of the mouse Kit gene in the progeny of heterozygotes with the null mutant Kit(tm1Alf) (a lacZ insertion). In spite of a homozygous wild-type genotype, t...

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Identifiers

PMID: 16724059
DOI: 10.1038/nature04674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16724059-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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