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Article

Development of inhibitory antibodies to therapeutic factor VIII in severe hemophilia A is associated with microsatellite polymorphisms in the HMOX1 promoter.

Haematologica - 1 Oct 2013

Repessé Yohann, Peyron Ivan, Dimitrov Jordan D, Dasgupta Suryasarathi, Moshai Elika Farrokhi, Costa Catherine, Borel-Derlon Annie, Guillet Benoit, D'Oiron Roseline, Aouba Achille, Rothschild Chantal, Oldenburg Johannes, Pavlova Anna, Kaveri Srinivas V, Lacroix-Desmazes Sébastien

Abstract excerpt

Induction of heme oxygenase-1, a stress-inducible enzyme with anti-inflammatory activity, reduces the immunogenicity of therapeutic factor VIII in experimental hemophilia A. In humans, heme oxygenase-1 expression is modulated by polymorphisms in the promoter of the heme oxygenase-1-encoding gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23716558
DOI: 10.3324/haematol.2013.084665
PMCID: PMC3789472

Genes

HMOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23716558-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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