Article
In non-severe hemophilia A the risk of inhibitor after intensive factor treatment is greater in older patients: a case-control study.
Journal of thrombosis and haemostasis : JTH - 1 Oct 2010
Kempton C L, Soucie J M, Miller C H, Hooper C, Escobar M A, Cohen A J, Key N S, Thompson A R, Abshire T C
Abstract excerpt
BACKGROUND: Twenty-five percent of new anti-factor VIII (FVIII) antibodies (inhibitors) that complicate hemophilia A occur in those with mild and moderate disease. Although intensive FVIII treatment has long been considered a risk factor for inhibitor development in those with non-severe disease, its strength of association and the influence of other factors have remained undefined. OBJECTIVE: To evaluate risk...
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