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Article

A hypothetical anti-neoplastic mechanism associated to reserve cells.

Journal of theoretical biology - 21 Nov 2004

Torres-Montaner Antonio, Hughes David

Abstract excerpt

Reserve-stem cells, the permanent cells of body tissues, are thought to be the progenitor cells of cancer. This concept originates from the assumption that accumulation of somatic mutations necessary for malignant transformation can only take place in cellular targets with a prolonged life span. The progeny of reserve cells entering the differentiative pathway would be protected from potential critical mutations...

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PMID: 15380388
DOI: 10.1016/j.jtbi.2004.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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