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Article

Comparative genomics search for losses of long-established genes on the human lineage.

PLoS computational biology - 1 Dec 2007

Zhu Jingchun, Sanborn J Zachary, Diekhans Mark, Lowe Craig B, Pringle Tom H, Haussler David

Abstract excerpt

Taking advantage of the complete genome sequences of several mammals, we developed a novel method to detect losses of well-established genes in the human genome through syntenic mapping of gene structures between the human, mouse, and dog genomes. Unlike most previous genomic methods for pseudogene identification, this analysis is able to differentiate losses of well-established genes from pseudogenes formed...

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Identifiers

PMID: 18085818
DOI: 10.1371/journal.pcbi.0030247
PMCID: PMC2134963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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